Endocrine Abstracts

Today prolactin (PRL) has been demonstrated to regulate more then 300 different biological functions, including metabolism during lactation and in subjects with hyperprolactinemia. However, the mechanisms for how PRL regulates the adipose tissue in humans and rodents have remained unclear. We recently reported PRL receptor (PRLR) expression in the adipose tissue of lactating and in PRL-transgenic mice. These results suggest PRLR-mediated effects in adipose tissue. However, to ...